This newspaper (reporter Diao Wenhui) researchers from the Cancer Hospital of the Chinese Academy of Medical Sciences, Sanya BGI Life Sciences Research Institute and other units reviewed 30 surgical resected tumor sample Cells that can promote pulled cells of tumor cells that can promote cells with tumor cells, and cells with tumor cells can promote cells of tumor cells in tumor cells, and cells of cells with cells, cells and cells with cells, and cells, and cells with cells, and cells, and cells with cells, and cells, and cells with cells, and cells, and cells with cells, and cells, and cells with cells, and cells, and cells, and cells with cells, and cells, and cells with cells, and cells, and cells with cells, and cells, and cells with cells, and cells, and cells with cells, and cells, and cells with cells, and cells, and cells, and cells, and cells with cells, and cells of cells, and cells, and cells with cells, and cells, and cells of cells, and细胞，细胞和CE的细胞LLS，细胞，细胞，细胞，细胞以及细胞的细胞，带有疼痛细胞的细胞可以在刺痛中建立肚子细胞中肿瘤细胞的细胞，从而改善患者的安全性。很少有人在“自然通讯”中发表了相关的研究结果。乳腺癌是女性最常见的恶性肿瘤之一。每年，我国将近30万名妇女被诊断出患有乳腺癌。乳腺癌治疗的一个主要问题是免疫细胞不足地进入微环境肿瘤。免疫细胞在肿瘤周围保持“漫游”，但很难深入肿瘤的主要区域，从而导致免疫疗法的影响有限。研究小组检查了来自23名乳腺癌患者的30个新鲜冷冻组织，其中包括23例主要乳腺癌和7个配对的转移性淋巴结样品，涵盖了所有4个分子亚型。通过合并时空，单细胞和成像，他们宣布了特定的DI主肿瘤和转移性淋巴结中各种细胞的置换，从而进一步阐明了细肿瘤微环境肿瘤结构。研究发现，肿瘤细胞提供了大部分样品，平均为56％。基质细胞和免疫细胞的比例在5％至10％之间。值得注意的是，与主要肿瘤相比，免疫细胞T，NK和B细胞浸润成对淋巴结转移的致癌作用。研究小组还检查了乳腺癌样品中的内皮细胞和平滑肌细胞，发现其中的静脉内皮细胞和静脉平滑肌细胞与空间密切相关，因此这种共定位可以促进肿瘤区域中免疫细胞的浸润，从而提高了安全率。这项研究对迄今为止所有人类癌症的空间结构提供了最全面的分析，提供了新的研究乳腺癌免疫疗法的方向和技术。相关论文信息：https：//dii.org/10.1038/s41467-025-58511-0
